George and Wheezy...

 Sherman Hemsley and Isabel Sanford as George and Louise Jefferson...they first appeared on "All in the Family" and then starred in "The Jeffersons."

In this photo they appeared together for the final time at the TV Land awards in February 2004.  Isabel Sanford would pass away a few months later on July 9, 2004.  Sherman Hemsley passed away on July 24, 2012.